Silk Fibroin/Poly-L-lactide Lactone Bi-layered Membranes for Guided Bone Regeneration

作     者：WANG Linbo REN Xiangxiang JIANG Ziyi MENG Kai ZHAO Huijing 王临博;任翔翔;蒋紫仪;孟凯;赵荟菁

作者机构：National Engineering Laboratory for Modern SilkCollege of Textile and Clothing EngineeringSoochow UniversitySuzhou 215123China Nantong Textile&Silk Industrial Technology Research InstituteNantong 226001China 

出 版 物：《Journal of Donghua University(English Edition)》 (东华大学学报（英文版）)

年 卷 期：2019年第36卷第6期

页      面：564-572页

学科分类：0821[工学-纺织科学与工程] 0817[工学-化学工程与技术] 08[工学] 0807[工学-动力工程及工程热物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 082101[工学-纺织工程] 0811[工学-控制科学与工程] 

基　　金：Natural Science Foundation for Key Program of the Jiangsu Higher Education Institutions,China(No.19KJA610004) Natural Science Foundation of Jiangsu Province,China(No.BK20161254) China Postdoctoral Science Foundation(No.2019M651947) Mandatory Projects of Nantong Municipal Science and Technology Plan,China(No.JC2018004) 

主　　题：silk fibroin(SF) poly-L-lactide lactone(PLCL) guided bone regeneration(GBR) oral health 

摘      要：After removal of the caries or diseased teeth,the alveolar ridge will undergo absorption and *** the amount of alveolar bone is insufficient,it will cause an inability to perform effective dental implant *** order to control the absorption and promote the repair and regeneration of alveolar ridge,a method of implanting guided bone regeneration(GBR)membranes at the extraction site is often *** this study,silk fibroin(SF)and poly-L-lactide lactone(PLCL)were used to prepare bilayered guided bone regeneration membranes,and its morphology,hydrophilicity,surface roughness and mechanical properties were *** the same time,the drug release behaviors and cell compatibility of the bilayered membranes were *** results showed that SF/PLCL bi-layered membranes had good mechanical properties and surface hydrophilicity,and the drug-loaded bi-layered membranes had good cell *** bilayered membranes fabricated in this study are of potential for applying in the oral health field to promote bone regeneration.