Recent advances in micro/nanoscale intracellular delivery

作     者：Mengjie Sun Xuexin Duan Mengjie Sun;Xuexin Duan

作者机构：State Key Laboratory of Precision Measuring Technology&InstrumentsTianjin UniversityTianjin300072China 

出 版 物：《Nanotechnology and Precision Engineering》 (纳米技术与精密工程（英文）)

年 卷 期：2020年第3卷第1期

页      面：18-31页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100602[医学-中西医结合临床] 10[医学] 0702[理学-物理学] 

基　　金：National Natural Science Foundation of China(NSFC No.61674114,91743110,21861132001) National Key Research and Development Program of China(2017YFF0204604) Tianjin Applied Basic Research and Advanced Technology(17JCJQJC43600) the Foundation for Talent Scientists of Nanchang Institute for Microtechnology of Tianjin University,and the 111 Project(B07014) 

主　　题：Drug delivery Physical approaches Cell membrane disruption Low dimension 

摘      要：Intracellular delivery enables the efficient drug delivery into various types of cells and has been a long-term studied topics in modern *** delivery with improved delivery efficacy requires considerable *** process is a critical step in many cellular-level studies,such as cellular drug therapy,gene editing delivery,and a series of biomedical research *** emergence of micro-and nanotechnology has enabled themore accurate and dedicated intracellular delivery,and it is expected to be the next generation of controlled delivery with unprecedented *** review focuses on several represented micro-and nanoscale physical approaches for cell membrane disruption-based intracellular delivery and discusses the mechanisms,advantages,and challenges of each *** believe that the deeper understanding of intracellular delivery at such lowdimensionwould help the research community to develop more powerful delivery technologies for biomedical applications.