Usefulness of DWI in the evaluation of pulmonary isolated lesions

作     者：Zhiyong Li Tingting Zhang Bin Xu Qiang Wei Rui Han Wei Liu Jianlin Wu 

作者机构：Department of Radiology the First Affiliated Hospital of Dalian Medical University Dalian 116011 China 

出 版 物：《The Chinese-German Journal of Clinical Oncology》 (中德临床肿瘤学杂志（英文版）)

年 卷 期：2010年第9卷第7期

页      面：388-390页

学科分类：0821[工学-纺织科学与工程] 07[理学] 08[工学] 082101[工学-纺织工程] 0701[理学-数学] 070101[理学-基础数学] 

主　　题：diffusion imaging neoplasm diagnosis 

摘      要：Objective： The aim of our study was to investigate the value of Diffusion-weighted MR imaging （DWl） for evaluating differential diagnosis of pulmonary isolated lesions. Methods： Twenty-seven consecutive patients enrolled in this study, all of whom underwent single direction DWl examinations and received a histologic and clinical diagnosis. Diffusion factor B value was 300, 500, 800 s/mm2, respectively. DWl images of twenty cases could be satisfied to measurement and diagnosis and success rate was percent 74. Among these, lung tuberculoma 5 cases, harmatoma 3 cases, peripheral lung cancer 12 cases. The apparent diffusion coefficient （ADC） values of the lesions were measured. Statistical analyses were performed with the independent samples t test for comparing difference of ADC values between malignant nodules and benign nodules at different 8 value. Results： DWI images of twenty cases could be satisfied and its success rate was percent 74. When B value was 300 s/mm2, ADC values of malignant nodules and benign nodules were 0.002192±0.0006091 mm2/s, 0.002454 ± 0.0007892 mm2/s, respectively, and P = 0.442. When B value was 500 s/mm2, ADC value of malignant nodules and benign nodules were 0.002065 ± 0.0006769 mm2/s, 0.002871± 0.0007746 mm2/s, respectively, and P = 0.033. When B value was 800 s/mm2, ADC value of malignant nodules and benign nodules were 0.001646 ± 0.0004292 mm2/s, 0.002651 ＋ 0.0008041 mm2/s, respectively, and P = 0.009. There were the most different between malignant nodules and benign nodules at B value 800 and statistical significance. Conclusion： Lung DWl imaging is helpful to diagnosis and differential diagnosis between malignant and benign isolated nodules. The ADC value of benign lesions was statistically higher than that of malignant tumors.