Construction of diaminobenzoquinone imines via ferrocene-initiated radical reaction of benzoquinone with amines

作     者：Yadong Feng Ying Liu Qi Fu Zhongai Zou Jinhai Shen Xiuling Cui Yadong Feng;Ying Liu;Qi Fu;Zhongai Zou;Jinhai Shen;Xiuling Cui

作者机构：College of Environment and Public HealthXiamen Huaxia UniversityXiamen 361024China Engineering Research Center of Molecular Medicine of Ministry of EducationKey Laboratory of Fujian Molecular MedicineKey Laboratory of Xiamen Marine and Gene DrugsSchool of Biomedical SciencesHuaqiao UniversityXiamen 361021China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2020年第31卷第3期

页      面：733-735页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(No.21572072) 111 Project(No.BC2018061) the financial support of Scientific Research Foundation of Xiamen Huaxia University(No.HX201807) Outstanding Youth Scientific Research Cultivation Plan in Fujian Province University(No.201808)。 

主　　题：Benzoquinone imines Ferrocene-initiated Radical process Benzoquinone Amines 

摘      要：A ferrocene-initiated radical reaction of benzoquinone with amines has been successfully developed for the direct access to diaminobenzoquinone imines in high yields,in which the comme rcially available and cheap ferrocene was employed as a radical initiator and TBHP was used as an oxidant.Moreover,this reaction could be achieved with low loading of ferrocene(0.5 mol%).This protocol is highly efficient with good substrate tolera nce and provides a new approach for the construction of benzoquinone imines with potential pharmaceutical interest.