Therapeutic potential role of exosomes for ischemic stroke

作     者：Zhihan Zhu Bikram Shah Kalyan Lukui Chen 

作者机构：Department of NeurosurgerySchool of MedicineSoutheast UniversityNanjing 210009JiangsuChina Department of NeurosurgeryIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510310GuangdongChina 

出 版 物：《Brain Science Advances》 (神经科学（英文）)

年 卷 期：2019年第5卷第2期

页      面：128-143页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81671819) 

主　　题：exosomes biology biogenesis therapy 

摘      要：Exosomes are extracellular vesicles with a diameter of 30–100 nm,which are released into the extracellular space by fusion of multivesicular and plasma *** vesicles actually play a distinct role in cell communication,although they were considered as membrane debris in the *** endosomal sorting complex required for transport(ESCRT)-dependent and ESCRT-independent mechanisms are currently considered to be involved in the sorting of exosomes,and the release of exosomes is related to the members of Rab protein family and SNARE *** recent years,the therapeutic potential of exosomes has become *** example,via the direct transplantation of exosomes,the ischemic area after stroke is reduced,and the neurological function is improved ***,they can be used as effective drug delivery vehicles due to their unique characteristics such as low immunogenicity and nanometer *** conclusion,exosomes provide a cell-free treatment for ischemic stroke.