Effects of total iridoid glycosides of Picrorhiza scrophulariiflora against non-alcoholic steatohepatitis rats induced by high-fat and high-sugar diet through regulation of lipid metabolism

作     者：Xu Xu Wei-ting Wang Zhuan-you Zhao Wen-gong Xi Bing Yu Chun-hua Hao Xin Li Wen-bin Hou Li-da Tang Xu Xu;Wei-ting Wang;Zhuan-you Zhao;Wen-gong Xi;Bing Yu;Chun-hua Hao;Xin Li;Wen-bin Hou;Li-da Tang

作者机构：State Key Laboratory of Drug Delivery Technology and PharmacokineticsTianjin Institute of Pharmaceutical ResearchTianjin 300193China State Key Laboratory of Pharmacokinetics and PharmacodynamicsTianjin Institute of Pharmaceutical ResearchTianjin 300193China Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear MedicineInstitute of Radiation MedicinePeking Union Medical College&Chinese Academy of Medical SciencesTianjin 300192China 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2020年第12卷第1期

页      面：67-72页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by National Science and Technology Major Project(No.2014ZX09101021-001) Science and Technology Planing Program of Tianjin Province(No.15ZXXYSY00070) 

主　　题：HOMA-IR leptin non-alcoholic steatohepatitis TNF-α total iridoid glycosides of Picrorhiza scrophulariiflora 

摘      要：Objective:To investigate the therapeutic effect of total iridoid glycosides of Picrorhiza scrophulariiflora(TIGP)on non-alcoholic steatohepatitis(NASH).Methods:SD rats were fed with high-fat and high-sugar diet for 8 weeks to establish *** were given orally at doses of 20,40 and 80 mg/kg/d for 4 *** assay(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),aspartate aminotransferase(AST),alanine aminotransferase(ALT),fasting plasma glucose(FPG),fasting insulin(FINS),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),chemokine-1(MCP-1),leptin(LEP)in serum were ***,TC,superoxide dismutase(SOD),malondialdehyde(MDA),and free fatty acid(FFA)in liver tissue were determined by colorimetric *** of hepatocytes and inflammation was performed by pathological ***:The results showed that TIGP significantly decreased TC,TG and FFA in liver tissue,increased SOD activity,decreased MDA content,decreased serum levels of TG,TC,HDL-C/LDL-C,ALT,AST,GLU,HOMA-IR,TNF-αand LEP,and in addition,improved steatosis of liver cells compared to ***:TIGP had anti-fatty liver effect against NASH rats induced by high-fat and high-sugar *** mechanism was related to the regulation of lipid metabolism and reduction of insulin resistance,through inhibition of oxidative stress and inflammation.