Whole-Brain Monosynaptic Inputs to Hypoglossal Motor Neurons in Mice

作     者：Han Guo Xiang-Shan Yuan Ji-Chuan Zhou Hui Chen Shan-Qun Li Wei-Min Qu Zhi-Li Huang Han Guo;Xiang-Shan Yuan;Ji-Chuan Zhou;Hui Chen;Shan-Qun Li;Wei-Min Qu;Zhi-Li Huang

作者机构：Department of PharmacologySchool of Basic Medical SciencesState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceInstitutes of Brain ScienceFudan UniversityShanghai 200032China Department of AnatomySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Pulmonary MedicineZhongshan HospitalFudan UniversityShanghai 200032China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2020年第36卷第6期

页      面：585-597页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (31530035,81420108015, 31671099,31871072,81570081,81770083 and 31971110) the National Basic Research Development Program of China (2015CB856401) the Program for Shanghai Outstanding Academic Leaders (to ZLH) the Shanghai Municipal Science and Technology Major Project (2018SHZDZX01) the National Key Research and Development Program of China (2018YFC1313600) 

主　　题：Hypoglossal motor neuron Monosynaptic input Rabies virus Respiration Sleep and wake 

摘      要：Hypoglossal motor neurons(HMNs) innervate tongue muscles and play key roles in a variety of physiological functions,including swallowing,mastication,suckling,vocalization,and *** of HMNs is associated with several diseases,such as obstructive sleep apnea(OSA) and sudden infant death *** A is a serious breathing disorder associated with the activity of HMNs during different sleep-wake *** the neural mechanisms by which the statedependent activities of HMNs are controlled may be helpful in providing a theoretical basis for effective therapy for ***,the presynaptic partners governing the activity of HMNs remain to be *** the present study,we used a cell-type-specific retrograde tracing system based on a modified rabies virus along with a Cre/loxP gene-expression strategy to map the whole-brain monosynaptic inputs to HMNs in *** identified 53 nuclei targeting HMNs from six brain regions:the amygdala,hypothalamus,midbrain,pons,medulla,and *** discovered that GAB Aergic neurons in the central amygdaloid nucleus,as well as calretinin neurons in the parasubthalamic nucleus,sent monosynaptic projections to *** addition,HMNs received direct inputs from several regions associated with respiration,such as the preBotzinger complex,parabrachial nucleus,nucleus of the solitary tract,and *** regions engaged in sleep-wake regulation(the parafacial zone,parabrachial nucleus,ventral medulla,sublaterodorsal tegmental nucleus,dorsal raphe nucleus,periaqueductal gray,and hypothalamus) also provided primary inputs to *** results contribute to further elucidating the neural circuits underlying disorders caused by the dysfunction of HMNs.