Type I vaccine-derived polioviruses in China from 1995 to 2019

作     者：Yong Zhang Shuangli Zhu Dongmei Yan Dongyan Wang Xiaolei Li Hui Zhu Hongqiu An Wenbo Xu Zhang Yong;Zhu Shuangli;Yan Dongmei;Wang Dongyan;Li Xiaolei;Zhu Hui;An Hongqiu;Xu Wenbo

作者机构：WHO WPRO Regional Polio Reference Laboratory and National Laboratory for PoliomyelitisNational Health Commission Key Laboratory for BiosafetyNational Health Commission Key Laboratory for Medical VirologyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Center for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China 

出 版 物：《Biosafety and Health》 (生物安全与健康（英文）)

年 卷 期：2019年第1卷第3期

页      面：155-158页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by the National Science and Technology Major Project of China(Project Nos.2018ZX10711001 2017ZX10104001 and 2018ZX10713002) 

主　　题：Type I Vaccine-derived poliovirus Phylogenetic analysis Neutralizing antigenic sites 

摘      要：A nation-wide case surveillance was conducted in China since 1995 for the objective of identifying acute flaccid paralysis(AFP)in children so that potential wild polioviruses and vaccine-derived poliovirus(VDPV)could be identified on *** outbreaks associated with type I circulating VDPVs,eight native independent type I ambiguous VDPVs(aVDPV),and one imported aVDPV were identified during the AFP case surveillance in China from 1995 to *** VP1 coding region of the Chinese type I VDPVs differed from the polio vaccine strain by 1.00%–3.75%(9–34 substitutions in 906 nucleotides).Most of the Chinese type I VDPV strains shared 4 amino acid substitutions in the neutralizing antigenic(NAg)sites:3 located at the BC loop,which formed the NAg site 1,and another at NAg site *** of the Chinese type I VDPVs identified during the AFP case surveillance were young VDPVs,which indicated a limited viral replication resulted from the administration of the initiating oral polio vaccine(OPV)*** can emerge and spread in isolated communities with immunity gaps and the circulation ceases following a mass immunization with *** such,high-quality surveillance permitted very early detection and response and it played a key role in stalling the widespread circulation of the emergent cVDPV strains in China.