Daphnane Diterpenoids from Trigonostemon lii and Inhibition Activities Against HIV‑1
作者机构：State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650204YunnanPeople’s Republic of China Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of SciencesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunming 650223YunnanPeople’s Republic of China School of Ethnic MedicineGuizhou Minzu UniversityGuiyang 550025GuizhouPeople’s Republic of China Institute of Molecular ScienceShanxi UniversityTaiyuan 030006ShanxiPeople’s Republic of China School of Basic MedicalKunming Medical UniversityKunming 650500YunnanPeople’s Republic of China
出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)
年 卷 期：2020年第10卷第1期
页 面：37-44页
学科分类：0710[理学-生物学] 1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 0832[工学-食品科学与工程（可授工学、农学学位）] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0901[农学-作物学] 0703[理学-化学] 100401[医学-流行病与卫生统计学] 0902[农学-园艺学] 100602[医学-中西医结合临床] 10[医学]
基 金：supported financially by grants from the National Science Foundation of China(21432010 and 81660612) Technological leading talent project of Yunnan(2015HA020) Yunnan Applied Basic Research Project-Kunming Medical University Union Foundation(2017FE467(-127),Scientific Research Fund Projects from the Department of Education of Yunnan(2016ZDX042) the Hundred-Talent Program of Kunming Medical University(60117190441)
主 题：Trigonostemon lii Daphnane diterpenoid Trigonolactone Anti-HIV
摘 要：Natural products are the important source for the discovery of more potent anti-HIV *** this study,six daphnane diterpenoids including three unreported structures were isolated from Trigonostemon lii,which showed signifcant activities against HIV-1 strains replication in the nanomolar/picomolar ***,these diterpenoids signifcantly inhibited the fusion of H9/HIV-1 IIIB cells with uninfected C8166 cells,with the EC50s from 1.06 to 8.73 ng/mL,and did not show any inhibition activities against HIV-1 reverse ***,all of the diterpenoids shows signifcant inhibitions against T20-resistan HIV-1 strains,PNL4-3gp41(36G)V38E,N42S and pNL4-3gp41(36G)V38A,*** results revealed that the six diterpenoids could be a new type of potential lead candidate as an HIV entry inhibitor,particularly for those infected by T20-resistant variants.
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