Hematopoietic Stem and Progenitor Cell(HSPC)Mobilization Responses to Different Exercise Intensities in Young and Older Adults
作者机构：Department of KinesiologyMcMaster UniversityHamiltonON L8S 4L8Canada Child and Youth Mental Health ProgramMcMaster University Medical CentreHamiltonON L8N 3Z5Canada
出 版 物：《Journal of Science in Sport and Exercise》 (体育运动科学（英文）)
年 卷 期：2020年第2卷第1期
页 面：47-58页
基 金：supported by a Natural Sciences and Engineering Research Council of Canada(NSERC)Grant(1455843) a NSERC Canadian Graduate Scholarship(CGS-D)
主 题：Exercise Hematopoietic stem cells Pmgenitor cells Aging F1ow cytometry
摘 要：Introduction Hematopoietic stem and progenitor cells(HSPC)are responsible for the reconstitution of blood cells and thought to contribute to peripheral tissue *** acute exercise in young adults,HSPC are mobilized from their niche in bone marrow into circulation,however the kinetics of mobilization following exercise is not well understood in older *** the present study,we aimed to investigate how exercise intensity influences mobilization of specific subpopulations of HSPC,and how mobilization is affected by *** Healthy older men(OM;69.9±2.0 years)and young men(YM;21.5±0.8 years)performed three separate bouts of exercise on a cycle ergometer:70%of their peak work rate(WRpeak)until volitional fatigue,30%of their WRpeak work matched to the 70%WRpeak trial,and a high intensity interval training(HIIT)*** samples were collected before,immediately post,and 10,30,and 60 min *** blood cells,hematocrit,and mononuclear cells isolated by density gradient centrifugation were quantified using flow *** Mononuclear cells,CD34+,CD34+/CD38+,CD34+/CD110+,CD3+/CD(16+56)+,CD11c+/CD123-,and CD11c-/CD123+cells per millilitre of blood increased immediately post-exercise,but predominately in the 70%WRpeak trial in both OM and *** Taken together,our evidence suggests that higher intensity exercise but also volume is necessary for the mobili-zation of ***,the pattern of mobilization was nearly identical in OM as compared to YM though to a lesser extent than their younger counterparts.
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