The roles of atypical protein kinase Cs(aPKCs) in the nervous system: targets for neuroregeneration?

作     者：Dennis Dik-Long Chau Kwok-Fai Lau Dennis Dik-Long Chau;Kwok-Fai Lau

作者机构：School of Life Sciences The Chinese University of Hong Kong 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第8期

页      面：1475-1476页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 081704[工学-应用化学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by funds from the Research Grants Council Hong Kong,Health and Medical Research Fund(Hong Kong) CUHK direct grant scheme the United College endowment fund the TUYF Charitable Trust 

主　　题：domains. subgroup system 

摘      要：The protein kinase C(PKC)family:PKC family is a subgroup of the AGC serine-threonine kinases that consists of 10 distinct members in mammals(Spitaler and Cantrell,2004).They all contain a C-terminal catalytic domain that is connected to the N-terminal regulatory *** are subdivided into three classes according to their structures and *** classical/conventional PKC isoforms possess tandem C1 domains that bind to their well-known activators diacylglycerol and phorbol esters and also contain a C2 domain that mediates the binding of Ca^2+-sensitive anionic phospholipids.