Innate and adaptive immunity in inflammatory bowel disease

作     者：Britta Siegmund Martin Zeitz 

作者机构：Medical Department I (Gastroenterology/Rheumatology/Infectious Diseases)Campus Benjamin FranklinCharité Universittsmedizin Berlin Hindenburgdamm 3012203 BerlinGermany 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第27期

页      面：3178-3183页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by SFB 633 of the Deutsche Forschungsgemeinschaft 

主　　题：Inflammatory bowel diseases Immune system 

摘      要：Inflammatory bowel diseases are the consequence of a dysregulated mucosal immune system. The mucosal immune system consists of two arms, innate and adaptive immunity, that have been studied separately for a long time. Functional studies from in vivo models of intestinal inflammation as well as results from genome-wide association studies strongly suggest a crossregulation of both arms. The present review will illustrate this interaction by selecting examples from innate immunity and adaptive immunity, and their direct impact on each other. Broadening our view by focusing on the cross-regulated areas of the mucosal immune system will not only facilitate our understanding of disease, but furthermore will allow identification of future therapeutic targets.