Adenosquamous carcinoma may have an inferior prognosis to signet ring cell carcinoma in patients with stages Ⅰ and Ⅱ gastric cancer
Adenosquamous carcinoma may have an inferior prognosis to signet ring cell carcinoma in patients with stages Ⅰ and Ⅱ gastric cancer作者机构：Department of Oncology (Division Ⅰ)Cancer CenterRenmin Hospital of Wuhan University
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2020年第12卷第1期
页 面：101-112页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the National Natural Science Foundation of China No.81670123 and No.81670144
主 题：Adenosquamous carcinoma Signet ring cell carcinoma Surveillance,Epidemiology,and End results Propensity score matching Prognosis Survival
摘 要：BACKGROUND Primary gastric adenosquamous carcinoma(ASC)is an exceedingly rare histological *** signet ring cell carcinoma(SRC)is a unique subtype with distinct tumor biology and clinical *** prognosis of gastric ASC vs SRC has not been well established to *** hypothesized that further knowledge about these distinct cancers would improve the clinical management of such *** To investigate the clinicopathological characteristics and prognosis of gastric ASC vs *** A cohort of gastric cancer patients was retrospectively collected from the Surveillance,epidemiology,and end results program *** 1:4 propensity score matching was performed among this *** clinicopathological features and prognosis of gastric ASC were compared with gastric SRC by descriptive ***-Meier method was utilized to calculate the median survival of the two groups of *** proportional hazard regression models were used to identify prognostic *** Totally 6063 patients with gastric ASC or SRC were identified.A cohort of 465 patients was recruited to the matched population,including 370 patients with SRC and 95 patients with *** ASC showed an inferior prognosis to SRC after propensity score *** the post-matching cohort,the median cancer specific survival was 13.0(9.7-16.3)mo in the ASC group vs 20.0(15.7-24.3)mo in the SRC group,and the median overall survival had a similar trend(P0.05).ASC and higher tumor-node-metastasis stage were independently associated with a poor survival,while radiotherapy and surgery were independent protective factors for improved *** survival analysis revealed that the prognosis of ASC was inferior to SRC only in stages I and II *** ASC may have an inferior prognosis to SRC in patients with stages I and II gastric *** study supports radiotherapy and surgery for the future management of this clinically rare entity.
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