Compounds of traditional Chinese medicine and neuropathic pain

作     者：LI Shun-Hua LI Lin YANG Ru-Nan LIANG Shang-Dong LI Shun-Hua;LI Lin;YANG Ru-Nan;LIANG Shang-Dong

作者机构：Neuropharmacology Laboratory of Physiology DepartmentMedical School of Nanchang UniversityNanchang 330006China Undergraduate Student of Class 155 of Nanchang University Queen Marry University of London Joint ProgrammeNanchang 330006China Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and DiseaseNanchang 330006China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2020年第18卷第1期

页      面：28-35页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 0703[理学-化学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：supported by the National Natural Science Foundation of China(Nos.81570735 8181101216 31560276 81970749 and 81870574) 

主　　题：Traditional Chinese medicine Diabetic neuropathic pain HIV-gp120-associated neuropathic pain Chronic constriction injury Nucleotide receptors 

摘      要：Neuropathic pain(NP)has become a serious global health issue and a huge clinical challenge without available effective treatment.P2 receptors family is involved in pain transmission and represents a promising target for pharmacological intervention.Traditional Chinese medicine(TCM)contains multiple components which are effective in targeting different pathological mechanisms involved in NP.Different from traditional analgesics,which target a single pathway,TCMs take the advantage of multiple components and multiple targets,and can significantly improve the efficacy of treatment and contribute to the prediction of the risks of NP.Compounds of TCM acting at nucleotide P2 receptors in neurons and glial cells could be considered as a potential research direction for moderating neuropathic pain.This review summarized the recently published data and highlighted several TCMs that relieved NP by acting at P2 receptors.