华法林治疗青斑样血管病变伴冷纤维蛋白血症及高同型半胱氨酸血症

作     者：Browning C.E. Callen J.P. 刘艳 

作者机构：310 East Broadway Louisville KY 40202 United States Dr 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2006年第2卷第3期

页      面：32-32页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100214[医学-肿瘤学] 10[医学] 

主　　题：青斑样血管病变 多种药物治疗 高同型半胱氨酸血症 华法林钠 蛋白血症 疼痛性溃疡 纤维 毛细血管扩张 男性患者 组织学检查 

摘      要：Background: Livedoid vasculopathy is an idiopathic, chronic disorder manifested by painful, purpuric macules on the lower extremities that superficially ulcerate, resulting in atrophic, stellate scars with peripheral telangiectasias and hyperpigmentation. Observations: A 50-year-old man presented with recurrent, painful ulcerations on the medial aspect of his malleoli and calves. The clinical presentation, histologic findings, and results of laboratory evaluation confirmed the diagnosis of livedoid vasculopathy in this case. Despite being refractory to treatment with multiple other medications, the lesions responded dramatically to oral warfarin sodium therapy. Conclusion: Treatment with warfarin may be a beneficial therapy for patients with livedoid vasculopathy.