Serological pattern “anti-HBc alone”:Characterization of 552 individuals and clinical significance

作     者：Antje Knll Arndt Hartmann Harald Hamoshi Karin Weislmaier Wolfgang Jilg 

作者机构：Institute of Medical Microbiology and HygieneUniversity of RegensburgRegensburgGermany Institute of PathologyUniversity of RegensburgRegensburgGermany 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第8期

页      面：1255-1260页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by the University of Regensburg Germany HWP grant for Antje Knll 

主　　题：HBV markers HBV serology Hepatitis B virus Hepatocellular carcinoma Occult HBV infection 

摘      要：AIM： To investigate the prevalence and clinical significance of ＂anti-HBc alone＂ in an unselected population of patients and employees of a university hospital in southern Germany. METHODS： All individuals with the pattern ＂anti-HBc alone＂ were registered over a time span of 82 mo. HBVDNA was measured in serum and liver samples, and clinical charts were reviewed. RESULTS： Five hundred and fifty two individuals were ＂anti-HBc alone＂ （of 3004 anti-HBc positive individuals; 18.4%）, and this pattern affected males （20.5%） more often than females （15.3%; P〈0.001）. HBV-DNA was detected in serum of 44 of 545 ＂anti-HBc alone＂ individuals （8.1%）, and in paraffin embedded liver tissue in 16 of 39 patients tested （41.0%）. There was no association between the detection of HBV genomes and the presence of biochemical, ultrasonic or histological signs of liver damage. Thirty-eight ＂anti-HBc alone＂ patients with cirrhosis or primary liver carcinoma had at least one additional risk factor. HCV-coinfection was present in 20.4% of all individuals with ＂anti-HBc alone＂ and was the only factor associated with a worse clinical outcome. CONCLUSION： In an HBV low prevalence area, no evidence is found that HBV alone causes severe liver damage in individuals with ＂anti-HBc alone＂. Recommendations for the management of these individuals are given.