Human endothelial senescence can be induced by TNF-α

作     者：Jianjun Zhou Yunfei Gao Hongfang Wang Quan Chen Caihong Wu Meifu Feng 

作者机构：The National Key Laboratory of Biomembrane and Membrane Biotechnology College of Life Sciences Peking University Beijing China The National Key Laboratory of Biomembrane and Membrane Biotechnology Institute of Zoology Chinese Academy of Sciences Beijing China Department of Cell Biology and Genetics College of Life Sciences Peking University Beijing China 

出 版 物：《Chinese Science Bulletin》 (Chin. Sci. Bull.)

年 卷 期：2002年第47卷第2期

页      面：118-122页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071008[理学-发育生物学] 

主　　题：TNF-α endothelial cells inflammation senescence. 

摘      要：TNF-α is one of the most important proin-flammatory cytokines in mediating multiple physio-patho-logical functions during immunological responses. Vascular endothelial cells, when stimulated by TNF-α, can increase the expression of multiple cytokines and cellular adhesion molecules and, in turn, actively promote the inflammatory responses by recruiting and activating of leukocytes to the inflammatory site. In addition to endothelial death induced by TNF-α, we found for the first time that TNF-α can also induce the human endothelial cells senescence. The induced senescent endothelial cells will display SA-B-Gal staining and they were arrested in G0-G1 phase. We found that △(?)m would always be up-regulated in response to TNF-α stimula-tion at early time but when the cells become senescent, △(?)m shows a tendency to decrease. It may reflect the sthenic func-tion of mitochondria at early time in response to TNF-α stimulation and decay when the endothelial cells were in-duced senescent. ROS