Effect of ^(125)I seeds and ^(103)Pd stents on proliferation of vascular smooth muscle cells

作     者：ZHU Jun, LUO Quan-Yong, ZHU Rui-Sen, LU Han-Kui (Shanghai 6th People’s Hospital, Shanghai 200233) 

作者机构：Shanghai 6th People's Hospital 200233 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：2002年第13卷第4期

页      面：218-223页

核心收录：

学科分类：08[工学] 1010[医学-医学技术（可授医学、理学学位）] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0807[工学-动力工程及工程热物理] 0827[工学-核科学与技术] 0703[理学-化学] 100106[医学-放射医学] 0702[理学-物理学] 0801[工学-力学（可授工学、理学学位）] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Yen Tjing Ling Medical Foundation 

主　　题：细胞增殖 125I 103Pd 血管肌肉细胞 

摘      要：This study aims at the theoretical and practical evidence for prevention of restenosis in *** smooth muscle cell(VSMC)model was established using adherent cell culture *** proliferation of VSMC was investigated by the cell counting method and 3H-TDR implementation *** results are as follows.(1) For ^125I-seeds,the inhibition rate was 29.3% at 74B1(P0.05),35.2% at 148Bq(P0.05)and 42.4% at 370Bq(P0.05),For ^103Pd-implanted stents,the inhibition rate was 14.7% at 4.44MBq(P0.05),24.0% at 5.92MBq(P0.05) and 38.0%at 7.4MBq(p0.05),There was no significant difference between the blank tests and non-radioactive tests.(2) 48 hours exposure from ^125I-seeds at 148Bq or ^103Pd-implanted stents at 7.4MBq did not result in VSMC s morphological alteration,but that from ^125I-seeds at 370Bq caused morphological changes,Both ^125I-seeds and ^103Pd0-implanted stents inhibit the VSMC DNA synthesis in *** inhibition effects are significantly related to their exposure duration and doses.