Hypoparathyroidism with Fahr’s syndrome: A case report and review of the literature

作     者：Yuan-Yuan Zhou Ying Yang Hong-Mei Qiu 

作者机构：Department of Endocrinology and MetabolismFourth Affiliated Hospital of Kunming Medical University and The Second People’s Hospital of Yunnan ProvinceKunming 650021Yunnan ProvinceChina Department of Endocrinology and MetabolismSixth Affiliated Hospital of Kunming Medical University and The People’s Hospital of Yuxi CityYuxi 653100Yunnan ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2019年第7卷第21期

页      面：3662-3670页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Endocrine Clinical Medical Center of Yunnan Province,No.ZX2019-02-02 Endocrine Clinical Medical Center of Yunnan Province,No.ZX2019-02-02 Natural Science Foundation of China(No.81760734 No.31660313) Natural Science Foundation of Yunnan Province(No.2017FA048 No.2017FE467) the fund of Diabetic Innovation Team(No.2019HC002) the fund of medical leader in Yunnan Province(No.L-201609) 

主　　题：Hypoparathyroidism Hypocalcemia Fahr’s syndrome Case report 

摘      要：BACKGROUND Hypoparathyroidism with basal ganglia calcification is clinically rare.Here,we report a case of Fahr’s syndrome due to hypoparathyroidism and review the literature in terms of etiology,clinical manifestation,diagnosis,and treatment.CASE SUMMARY A 62-year-old man experienced repeated twitching of both hands in recent 10 years.On July 28,2017,the patient was admitted to our hospital due to slow response and speech difficulties.On medical examinations,he had a positive Chvostek sign,while no Albright’s hereditary osteodystrophy signs or history of neck surgery or radiation,and his family members had no similar medical history.Laboratory examinations revealed hypocalcemia,hyperphosphatemia,and low parathyroid hormone(PTH)levels.Computed tomography revealed basal ganglia calcification.Based on these investigations,a diagnosis of Fahr’s syndrome due to hypoparathyroidism was suggested.After receiving intravenous calcium gluconate to relieve symptoms,the patient continued to take oral calcium carbonate and calcitriol for treatment.CONCLUSION The possibility of hypoparathyroidism should be considered in patients with chronic hypocalcemia,recurrent tetany,and even neuropsychiatric symptoms.Hypoparathyroidism is a common cause of basal ganglia calcification.Therefore,it is recommended that blood calcium,phosphorus,and PTH levels should be measured in all individuals with basal ganglia calcification to exclude hypoparathyroidism.