Paraben Content in Adjacent Normal-malignant Breast Tissues from Women with Breast Cancer

作     者：Mohammad Mehdi Amin Maryam Tabatabaeian Afsane Chavoshani Elham Amjadi Majid Hashemi Karim Ebrahimpour Roya Klishadi Sedigheh Khazaei Maijan Mansourian 

作者机构：Environment Research CenterResearch Institute for Primordial Prevention of Non-Communicable DiseaseIsfahan University of Medical SciencesIsfahanIran Department of Environmental Health EngineeringSchool of HealthIsfahan University of Medical SciencesIsfahanIran Breast SurgeonBoard certificate in general surgery in Anahid ClinicIsfahanIran Student Research CommitteeIsfahan University of Medical SciencesIsfahanIran Anatomical Clinical PathologistPoursina Hakim Digestive Diseases Research CenterIsfahan University of Medical SciencesIsfahanIran Environmental Health EngineeringSchool of Public HealthKerman University of Medical SciencesKermanIran Environmental Health Engineering Research CenterKerman University of Medical SciencesKermanIran Child Growth and Development Research Cen terResearch Institute for Primordial Prevention of Non-Communicable DiseaseIsfahan University of Medical SciencesIsfahanIran MicrobiologistMolecular Pathology Research CenterImam Reza HospitalKermanshah University of Medical SciencesKermanshahIran Department of Biostatistics and EpidemiologySchool of HealthIsfahan University of Medical SciencesIsfahanIran 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2019年第32卷第12期

页      面：893-904页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by Isfahan University of Medical Sciences Isfahan Iran [Research Project code:397158] 

主　　题：Paraben Breast cancer Malignant tissues Normal tissues Demography Risk factors 

摘      要：Objective Accumulation of estrogenic compounds and other carcinogens in normal breast tissues contributes to unpredictable breast cancer incidence during adolescence and throughout *** assess the role of parabens in this phenomenon,the paraben content of adjacent normal-malignant breast tissues is measured in women with breast cancer living in Isfahan Province,*** Adjacent normal-malignant breast tissue samples were obtained from 53 *** parabens including methyl-paraben(Me PB),ethyl-paraben(Et PB),propyl-paraben(Pr PB),and butylparaben(Bu PB)were extracted from the sample supernatant and then subjected to gas chromatography *** Some risk factors for breast cancer were stimulated by parabens in adjacent malignant-normal breast tissues among young and middle-aged women with breast *** observed a significant association for dose-response pattern of Me PB[OR=98.34(11.43–185.2),P=0.027]for both ER+and PR+women and Me PB[OR=164.3(CI:112.3–216.3),P0.001]for HER2+women than women with negative *** risk of 95-fold increase in Me PB dose and 164-fold increase in∑PBs dose were significant for women with hereditary breast cancer in first-degree *** These results may promote future epidemiology studies and strategies to improve women s lifestyle and consume paraben-free products.