Trace analysis of mefenamic acid in human serum and pharmaceutical wastewater samples after pre-concentration with Ni-Al layered double hydroxide nano-particles

作     者：Hossein Abdolmohammad-Zadeh Fatemeh Morshedzadeh Elaheh Rahimpour 

作者机构：Department of ChemistryFaculty of SciencesAzarbaijan Shahid Madani University35 Km Tabriz-Marageh RoadP.O.Box 53714-161TabrizIran Department of ChemistryPayame Nour University of Tabriz 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2014年第4卷第5期

页      面：331-338页

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 0817[工学-化学工程与技术] 0703[理学-化学] 0702[理学-物理学] 10[医学] 

基　　金：support from the Research Council of Azarbaijan Shahid Madani University (ASMU Iran) 

主　　题：Mefenamic acid Solid phase extraction Nano-sorbent Nickel-aluminum layereddouble hydroxide Ultraviolet spectroscopy 

摘      要：In this work, the nickel-aluminum layered double hydroxide （Ni-Al LDH） with nitrate interlayer anion was synthesized and used as a solid phase extraction sorbent for the selective separation and pre-concentration of mefenamic acid prior to quantification by UV detection at λmax ？ 286 nm. Extraction procedure is based on the adsorption of mefenamate anions on the Ni-Al（NO3？ ） LDH and/or their exchange with LDH interlayer NO3？ anions. The effects of several parameters such as cations and interlayer anions type in LDH structure, pH, sample flow rate, elution conditions, amount of nano-sorbent and co-existing ions on the extraction were investigated and optimized. Under the optimum conditions, the calibration graph was linear within the range of 2-1000 mg/L with a correlation coefficient of 0.9995. The limit of detection and relative standard deviation were 0.6 mg/L and 0.84% （30 mg/L, n ？ 6）, respectively. The presented method was successfully applied to determine of mefenamic acid in human serum and pharmaceutical wastewater samples.