The Effect of Balanced Hypocaloric Diet on the Anthropometric and Basic Metabolic Indicators in Infertile Women with Gluteofemoral Obesity
The Effect of Balanced Hypocaloric Diet on the Anthropometric and Basic Metabolic Indicators in Infertile Women with Gluteofemoral Obesity作者机构：GA Ushakova Department of Obstetrics and Gynecology Kemerovo State Medical University Kemerovo Russia Hospital Therapy and Clinical Pharmacology Department Kemerovo State Medical University Kemerovo Russia The Department of Obstetrics & Gynecology College of Medicine and Health Sciences (CM & HS) United Arab Emirates University Al-Ain UAE The Department of Obstetrics & Gynecology Tawam Hospital Al-Ain UAE The Department of Obstetrics & Gynecology Faculty of Medicine Mutah University Karak Jordan The Department of Obstetrics and Gynecology Sechenov First Moscow State Medical University (Sechenov University) Moscow Russia.
出 版 物：《Open Journal of Obstetrics and Gynecology》 (妇产科期刊（英文）)
年 卷 期：2019年第9卷第10期
页 面：1325-1335页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Obesity Reproductive Age Infertility Diet Therapy Anovulation
摘 要：Purpose: To evaluate the effect of balanced hypocaloric diet therapy on the anthropometric and basic metabolic indicators in obese women with infertility. Methods: The follow up interventional clinical study included 23 infertile women in reproductive age with grade I gluteofemoral obesity. All patients have prescribed a balanced hypocaloric diet (1200 kcal/day), underwent exercise and behavioral therapy. Before and after 12-month treatment, an anthropometric study was conducted, determining the level of metabolic and hormonal indicators. Results: The total final number of study participants was 20 patients. A decrease in body weight was achieved in 87% of patients from 4 to 24 kg, on the average, by 10.58 ± 5.70 kg, there was also a decrease in BMI from 32.53 ± 1.40 to 28.55 ± 2.50 kg/m2 (p 0.001). The decrease in body weight was accompanied by a statistically significant decrease in leptin levels (p 0.001), E1 (p = 0.049), E2 (p = 0.032), fasting glucose (p 0.001), HOMA-IR (p = 0.002), cholesterol (p 0.001), TG (p = 0.004), LDL-C (p = 0.001), atherogenic index of plasma (p 0.001) and an increase in progesterone levels (p = 0.030). Ovulatory menstrual cycles were resumed in all women (p = 0.007) and pregnancy occurred within a year in 1 patient. Conclusion: The implementation of a hypocaloric diet for 12 months in infertile women with first-degree obesity helps to normalize metabolic and hormonal indicators, reduces body weight and restores ovulatory menstrual cycle in all patients.
维普期刊数据库