How Long to Treat with Bisphosphonates?

作     者：Fahad M. Alshahrani Mussa H. Almalki 

作者机构：Family Medicine Department King Abdulaziz Medical City National Guard Riyadh Saudi Arabia College of Medicine King Saud bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia Obesity Endocrine and Metabolism Center King Fahad Medical City Riyadh Saudi Arabia 

出 版 物：《Health》 (健康（英文）)

年 卷 期：2015年第7卷第12期

页      面：1615-1621页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Osteoporosis Bisphosphonate Drug Holiday Fragility Fracture Bone Mineral Density Bone Turnover Markers 

摘      要：Bisphosphonate class of drugs, the most commonly prescribed for the treatment of osteoporosis, is effective in preventing and treating bone loss and fractures. However, the treatment duration and the applicability of “drug holidays for bisphosphonates need optimization in order to minimize long-term exposure. Drug holidays may prevent potential adverse events while still maintaining some degree of antifracture efficacy via residual antiresorptive activity by retained bisphosphonates. Patients receiving bisphosphonates, who are at low-moderate risk of fracture, are potential candidates for a drug holiday. However, for high-risk patients or patients with previous history of fragility fractures, the benefits of continuing bisphosphonate therapy considerably out-weigh their potential harm. Evidence-based guidelines regarding starting and stopping a drug holiday are not available;therefore, it is appropriate to monitor patients on a drug holiday to assess a declining antiresorptive effect. In case of a significant rise in bone turnover markers or significant decrease in bone mineral density, it may be time to restart therapy.