Selective Monoprotection of Symmetrical Diols in a Flow Reactor
Selective Monoprotection of Symmetrical Diols in a Flow Reactor作者机构：Department of Pharmaceutical Sciences Yokohama University of Pharmacy Yokohama Japan
出 版 物：《International Journal of Organic Chemistry》 (有机化学国际期刊（英文）)
年 卷 期：2018年第8卷第2期
页 面：264-271页
主 题：Desymmetrization Selective Monoprotection Flow Synthesis Diols Tetrahydropyranylation
摘 要：Desymmetrization reactions provide a powerful approach for the construction of complex molecules. Various methods have been developed for the selective monoprotection of symmetrical diols;however, their application to large-scale operations is limited. In this study, the monotetrahydropyranylation of symmetrical diols in a flow reactor has been developed, whereby the length of the flow reactor tube and the amount of acid were optimized. A higher selectivity for the monoprotected derivative was observed when the reaction was performed in a flow reactor compared with that observed in a conventional batch experiment. The efficient flow method developed herein can be applied to large-scale synthesis by numbering up the flow reactor without affecting the selectivity and yield. Since monoprotection can be achieved without using a large excess of diol, our developed flow method is effective when expensive diol must be used.
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