Immune Control of Equine Infectious Anemia Virus Infection by Cell-Mediated and Humoral Responses

作     者：Elissa J. Schwartz Kasia A. Pawelek Karin Harrington Richard Cangelosi Silvia Madrid 

作者机构：Department of Mathematics and Computational Science University of South Carolina Beaufort Bluffton SC USA Department of Mathematics Washington State University Pullman WA USA Department of Mathematics Washington State University Pullman WA USASchool of Biological Sciences Washington State University Pullman WA USA School of Biological Sciences Washington State University Pullman WA USA 

出 版 物：《Applied Mathematics》 (应用数学（英文）)

年 卷 期：2013年第4卷第8期

页      面：171-177页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Deterministic Model Virus Infection Equine Infectious Anemia Virus Immune Response Antibodies Cy-totoxic T Lymphocytes 

摘      要：Equine Infectious Anemia Virus (EIAV) is a retrovirus that establishes a persistent infection in horses and ponies. The virus is in the same lentivirus subgroup that includes human immunodeficiency virus (HIV). The similarities between these two viruses make the study of the immune response to EIAV relevant to research on HIV. We developed a mathematical model of within-host EIAV infection dynamics that contains both humoral and cell-mediated immune responses. Analysis of the model yields results on thresholds that would be necessary for a combined immune response to successfully control infection. Numerical simulations are presented to illustrate the results. These findings have the potential to lead to immunological control measures for lentiviral infection.