Hepatic macrophages in drug-induced liver injury

作     者：Zhao Shan Cynthia Ju Zhao Shan;Cynthia Ju

作者机构：Center for Life SciencesSchool of Life SciencesYunnan UniversityKunmingChina Department of AnesthesiologyUTHealth McGovern Medical SchoolHoustonTXUSA 

出 版 物：《Liver Research》 (肝脏研究（英文）)

年 卷 期：2019年第3卷第3期

页      面：170-175页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by USA National Institutes of Health(NIH)funds R01DK109574 and R01DK122708(C.Ju) 

主　　题：Hepatic macrophages Acetaminophen(APAP) Drug Liver injury Intrinsic drug-induced liver injury(DILI) Idiosyncratic DILI 

摘      要：Drug-induced liver injury(DILI)is a major public health *** DILI,for example,acetaminophen overdose accounts for half of acute liver failure in the United ***,the most problematic type of DILI affecting drug development and health care is idiosyncratic DILI,which occurs unpredictably in a small population of patients taking the drug and the latency could be several weeks to *** knowledge on the pathogenesis of DILI suggest that hepatic macrophages play a central role in the initiation,progression and restoration stages of DILI,which make hepatic macrophages attractive as therapeutic *** macrophages consist of liver resident macrophages(also known as Kupffer cells,KCs)and infiltrating monocyte-derived macrophages(MoMF).There is a growing appreciation that hepatic macrophage is very plastic,and assumes diverse phenotypes and functions in response to micro-environmental *** this review,we will summarize studies on the role of hepatic macrophages in both intrinsic DILI and idiosyncratic DILI,followed by discussing the prognostic and therapeutic potentials of targeting hepatic macrophages and the obstacles in studying hepatic macrophages.