Microbiome dysbiosis and alcoholic liver disease

作     者：Fengyuan Li Craig J.McClain Wenke Feng Fengyuan Li;Craig J.McClain;Wenke Feng

作者机构：Department of MedicineDepartment of Pharmacology and ToxicologyAlcohol Research CenterUniversity of LouisvilleLouisvilleKYUSA 

出 版 物：《Liver Research》 (肝脏研究（英文）)

年 卷 期：2019年第3卷第3期

页      面：218-226页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the USA National Institutes of Health(NIH)grants(R01AA023190-01 1P50AA024337-01,1P20GM113226-01,1U01AA026926-01,1U01AA026980-01,1U01AA022489-01A1,1R01AA023681-01) a grant from VA(1I01BX002996-01A2) 

主　　题：Microbiome Dysbiosis Alcoholic liver disease(ALD) 

摘      要：Microbiome dysbiosis is strongly associated with alcoholic liver disease(ALD).Recent studies on comprehensive analyses of microbiome compositional and functional changes have begun to uncover the mechanistic relation between microbiome and the pathogenesis of ***,targeting the microbiome has become a potential strategy for the prevention and treatment of *** this review,we summarize the clinical evidence of microbiome dysbiosis in ALD patients,and experimental advances in microbiome and metabolomic functional changes in animals with different species and genetic backgrounds in *** also summarize the studies in humanized intestinal microbiome and fecal microbiota transplantation in *** introduce new developments in the studies on the role of the circulating bacterial microbiome,oral bacterial microbiome and fungal microbiome in the development of *** highlight the potential mechanisms by which microbiome dysbiosis contributes to ALD,including short chain fatty acid changes,bile acid metabolism,intestinal barrier function,release of bacterial and fungal products,and *** addition,we summarize the recent developments targeting the microbiome in prevention and treatment of ALD,including dietary nutrient interference,herbal medicine,antibiotics,anti-fungal agents,probiotics,engineered bacterial therapy,fecal transplantation and oral *** recent preclinical studies have advanced our understanding of the microbiome and ALD,clinical studies,especially prospective studies with large samples,are needed to better understand the cause-effect of microbiome dysbiosis in *** new precision-based strategies targeting the microbiome are expected to be developed as more effective therapies in ALD.©2019 The Third Affiliated Hospital of Sun Yat-sen *** Services by Elsevier *** behalf of KeAi Communications Co.,*** is an open access article under the CC BY-NC-ND license.