3D Nanocomposite Hydrogel Scaffolds Fabricated by Rapid Prototyping for Bone Tissue Engineering

作     者：许杜亮 张建光 莫秀梅 

作者机构：College of ChemistryChemical Engineering and BiotechnologyDonghua University 

出 版 物：《Journal of Donghua University(English Edition)》 (东华大学学报（英文版）)

年 卷 期：2014年第31卷第5期

页      面：630-634页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：National Natural Science Foundations of China(Nos.30973105,31271035) Science and Technology Commission of Shanghai Municipality,China(No.11nm0506200) Ph.D.Programs Foundation of Ministry of Education of China(No.20130075110005) 

主　　题：colloidal gels rapid prototyping gelatin nanoparticles scaffold bone tissue engineering 

摘      要：Colloidal gels made of oppositely charged nanoparticles are a novel class of hydrogels and can exhibit pseudoplastic behavior which will enable them to mold easily into specific *** moldable gels can be used as building blocks to self-assemble into integral scaffolds from bottom to up through electrostatic ***,they are too weak to maintain scaffold morphology just depending on interparticle interactions such as Van der Waals attraction and electrostatic forces especially for bone tissue *** this study,oppositely charged gelatin nanoparticles were firstly prepared by two-step desolvation method,followed by the mixture with water to form colloid *** solve the problem of weak mechanical performance of colloid gels, gelatin macromolecules were introduced into the prepared gels to form blend *** blend gels can be easily processed into three-dimensional( 3D) porous scaffolds via motor assisted microsyringe( MAM)system,a nozzle-based rapid prototyping technology,under mild *** fabrication the scaffolds were crosslinked by glutaraldehyde( GA,25% solution in water by weight),then the crosslinked gelatin macromolecules network could form to improve the mechanical properties of colloid *** average particle size and zeta potential of gelatin nanoparticles were measured by NanoZS *** morphology and microstructures of scaffolds were characterized by macroscopic *** mechanical properties of the scaffolds were studied by a universal material testing machine.