Influencing factors of serum indoxyl sulfate (IS) concentration in peritoneal dialysis (PD) patients
腹膜透析(PD)患者血清硫酸吲哚酚(IS)浓度的影响因素作者机构：Department of Nephrology Minhang Hospital Fudan University Shanghai 201100 China Department of Nephrology Zhongshan Hospital Fudan University Shanghai 200032 China
出 版 物：《Fudan University Journal of Medical Sciences》 (Fudan Univ. J. Med. Sci.)
年 卷 期：2019年第46卷第4期
页 面：466-471页
基 金：4th Shanghai Young Top-notch Talents Plan Scientific Research Foundation for Young Talents of Minhang District Central Hospital, (2019MHLC05) National Natural Science Foundation of China, NSFC, (81570600)
主 题：Dialysis adequacy Indoxyl sulfate (IS) Peritoneal dialysis (PD) Residual renal function
摘 要：Objective: Serum indoxyl sulfate (IS) concentration in peritoneal dialysis (PD) patients was significantly lower than that in hemodialysis patients. To analyze the influencing factors of serum IS concentration in PD patients. Methods: Continuous ambulatory PD (CAPD) patients in stable condition and assessed regularly in Zhongshan Hospital, Fudan University were enrolled. Baseline demographic, serum IS concentration and laboratory test data were collected, peritoneal equilibration test (PET) and dialysis adequacy were performed to assess their dialysis condition. Results: Total 169 CAPD patients were enrolled. Analysis results showed: there was no significant difference in sex, age, anemia and nutritional status between anuric and non-anuric patients. Anuric patients had lower IS concentration [(18. 74±11. 30) μg/mL vs. (28. 05±13. 98) μg/mL, P0. 001] and better dialysis adequacy [tKt/v: 2. 20±0. 60 vs. 1. 84±0. 43, P0. 001;tCcr: (71. 68±22. 84) L/wk vs. (53. 66±11. 16) L/wk, P0. 001]. Neither anuric nor non-anuric patients grouped by tKt/v there was no significant difference in IS concentration between patients with different dialysis adequacy. While grouped by tCcr, serum IS level in non-anuric patients with good PD adequacy was much lower than those with inadequate PD. There was no difference in serum IS levels among patients with different peritoneal transport characteristics. Micro-inflammation and malnutrition were more pronounced in high transport group. Univariate and multivariate analyses all showed that there were significant correlations between IS and PD duration, Scr, p-cresly sulfate (PCS), residual renal function (RRF), tCcr and prealbumin. The correlation between IS and tCcr was still significant after adjusted PD duration and urine amount. Conclusions: For CAPD patients, RRF is very important for IS clearance. Peritoneal transport characteristics have no significant effect on serum IS level. PD duration, nutritional status, RRF and PD adequacy are