A small molecule cocktail breaks the bottleneck of human primary hepatocytes culture

作     者：Yuchen Xia 

作者机构：State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology School of Basic Medical Sciences and Renmin Hospital of Wuhan University 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2019年第64卷第18期

页      面：1293-1294页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：diseases clinical culture 

摘      要：It is estimated that more than 300 million people in China are suffering from different liver diseases including viral hepatitis,fatty liver,alcoholic liver,liver fibrosis,cirrhosis and liver cancer,of which about 400,000 people die each year[1].The clinical resolution of these diseases relies largely on the breakthroughs from basic research.Human primary hepatocytes(PHHs)have long been considered as thegold standardfor in vitro liver disease research models.However,there are still a number of limitations,like high donor variability,short life spans and limited availability.