LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons

作     者：Fang Yuan Kai-Heng Fang Yuan Hong Shi-Bo Xu Min Xu Yufeng Pan Yan Liu Fang Yuan;Kai-Heng Fang;Yuan Hong;Shi-Bo Xu;Min Xu;Yufeng Pan;Yen Liu

作者机构：Institute for Stem Cell and Neural RegenerationSchool of PharmacyNanjing Medical UniversityNanjing 211166China Key Laboratory of Developmental Genes and Human DiseaseInstitution of Life SciencesSoutheast UniversityNanjing 2100096China State Key Laboratory of Reproductive MedicineNanjing Medical UniversityNanjing 211166China Co-innovation Center of NeuroregenerationNantong UniversityNantong 226019China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2020年第11卷第4期

页      面：286-291页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：We thank Dr.Su-Chun Zhang(Waisman Center and WiCell Research Institute at the University of Wisconsin)for kindly providing the AAVS1-TALEN plasmids and crispr-cas9 plasmids.This study was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA16010306) the National Natural Science Foundation of China Grants(Grant Nos.81922022,91849117,and 81471301) the National Key Research and Development Program of China(2019YFA0802703 and 2016YFC1306703) the Jiangsu Outstanding Young Investigator Program(BK20160044) the Jiangsu Province's Innovation Program,Postgraduate Research and Practice Innovation Program of Jiangsu Province 

主　　题：originated migrate MGE 

摘      要：Dear Editor,GABAergic interneurons(GIs)play an essential inhibitory role in regulating neural circuitry and neurological *** 54%GABAergic interneuron population originated from medial ganglionic eminence(MGE)at E13.5 in rodents(Butt et al.,2005),and migrated from MGE to dorsal cortex tangentially starting at E13-14 after the GABAergic neurons become *** of GABAergic interneurons causes severe neurological diseases,such as autism,schizophrenia and *** years,many studies have shown transplantation of GIs improved the neuronal function of animal models such as epilepsy,neuropathic pain,and fear erasure(Braz et al.,2012;Cunningham et al.;Yang et al.,2016).Since migration is the intrinsic nature of GIs,regulation of GIs migration could be essential for cell ***,the mechanism of human GIs migration remains unknown,which brings difficulties to control cell migration after transplantation.