A Convenient Method for the Synthesis of Aminomethylmonoalkylphosphinate

作     者：Ding Derong Yan Guang 

作者机构：Department of Pharmaceutical Sciences College of Pharmacy University of Kentucky Rose Street Lexington KY 40536-0082 USA Department of Biomedical and Pharmaceutical Sciences Idaho State University Pocatello Idaho 83209 USA 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2012年第30卷第8期

页      面：1906-1908页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 083201[工学-食品科学] 

主　　题：aminomethylmonoalkylphosphinate nucleophilic addition Mitsunobu reaction 

摘      要：Starting from the readily available 4-methylbenzoic acid, an efficient protocol for the preparation of ethyl 4- （aminomethyl） benzyl （methyl） phosphinate （1）, a novel aminomethylmonoalkylphosphinate was reported in this communication. The important step involves the selective monochlorination of phosphonic ester by POC13 and forming the phosphonochloridate, and followed by nucleophilic addition of CH3MgBr to the acid chloride interme- diate.