Global gene expression profiles for the growth phases of Trichophyton rubrum

作     者：XU XingYe LIU Tao LENG WenChuan DONG Jie XUE Ying YANG HanChuna JIN Qi 

作者机构：Key Laboratory of Animal Epidemiology and Zoonosis Ministry of Agriculture and State Key Laboratory of Agrobiotechnology College of Veterinary Medicine China Agricultural University Beijing 100094 China State Key Laboratory for Molecular Virology and Genetic Engineering Institute of Pathogen Biology Chinese Academy of Medical Sciences Beijing 100176 China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2011年第54卷第7期

页      面：675-682页

核心收录：

学科分类：0710[理学-生物学] 090502[农学-动物营养与饲料科学] 07[理学] 08[工学] 0905[农学-畜牧学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：supported by the National Natural Science Foundation of China (Grant No. 30870104) the Eleven-Fifth Mega-Scientific Project on Infectious Diseases,China (Grant Nos. 2008ZX10401-3 and 2009ZX10004-303) an intramural grant from the Institute of Pathogen Biology,Chinese Academy of Medical Sciences (Grant No. 2006IPB008) 

主　　题：Trichophyton rubrum gene expression prof'fles cDNA microarray growth phases 

摘      要：Trichophyton rubrum （T. rubrum） is a common superficial fungus. Molecular and genetic studies of T. rubrum are still limited. In this paper, we report the global analysis of gene expression profiles at different growth phases using cDNA microarray technology. A total of 2044 differentially expressed genes were obtained and clustered into three expression patterns. Our data confirmed previous results that many mRNAs were pre-stored in the conidia of T. rubrum. Transcriptional profiling and function analysis showed that some glycolytic enzymes share similar expression patterns and may be coregulated during the transi- tion of growth phases. Some genes involved in small GTPase signaling pathways, and in cAMP-dependent and MAPK regulation pathways were induced in response to the growth dynamics of T. rubrum. Although the detailed biological roles of these Z rubrum genes are still unknown, our results suggest that these genes may be involved in regulation mechanisms in the life cycle of the fungus.