Expression of hTERT, p53 and PCNA in Cystitis Glandularis

作     者：位志峰 叶章群 陈志强 WEI Zhifeng,YE Zhangqun2,CHEN Zhiqiang 1 Department of Urology,Nanjing General Hospital of Nanjing Military Command of PLA,Nanjing 210002 Jiangsu,China 2 Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China Department of Urology,Nanjing General Hospital of Nanjing Military Command of PLA,Nanjing 210002 Jiangsu,China

作者机构：Department of Urology Nanjing General Hospital of Nanjing Military Command of PLA Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：2007年第27卷第4期

页      面：437-439页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This project was supported by a grant from the Hubei Pro-vincial Natural Sciences Foundation (No 2005ABA164) 

主　　题：cystitis glandularis human telomere reverse transcriptase p53 proliferating cell nuclear antigen 

摘      要：To examine the expression of human telomere reverse transcriptase （hTERT）, p53 and proliferating cell nuclear antigen （PCNA） in cystitis glandulafis, 38 patients were divided into two grouips： group A （including 18 cases of papillary cystitis glandularis） and group B （including 20 subjects with normal bladder mucosa）. All the cases were immunohistochemically examined by using antibodies specifically against p53 and PCNA, and hTERT was determined by in situ hybridization. hTERT was found in 6 cases （33.3%） and p53 was detected in 4 cases （22.2%） in group A, while they were not detected in group B. There were significant differences in hTERT and p53 expression between groups A and B （P〈0.05 for both）. PCNA was detected in 7 cases （38.9%） in group A and 1 case （5.0%） in group B, and significant difference in PCNA expression was found between the two groups （P〈0.05）. The expressions of hTERT, p53 and PCNA were significantly higher in group A than in group B, suggesting that papillary cystitis glandularis is predisposed to cancerous change, and p53, PCNA, hTERT may be related to the malignant alteration.