3D-QSAR Studies of Dimethoxyphenoxyphenoxy pyrimidines and Analogues

作     者：LI Ai Xiu WANG Jin Ling SU Hua Qing MIAO Fang Ming (Institute of Chemical Crystallography, Tianjin Normal University, Tianjin, 300074) LI Ai-Xiu;WANG Jin-Ling;SU Hua-Qing;MIAO Fang-Ming

作者机构：天津师范大学 天津 3 0 0 0 74 

出 版 物：《Chinese Journal of Structural Chemistry》 (结构化学(英文版))

年 卷 期：2000年第19卷第2期

页      面：107-111页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Supported by the Key Discipline Fund of Tianjin Higher Education in China ( 972 0 3 ) 

主　　题：D QSAR photosystem Ⅱinhibitor CoMFA 

摘      要：Three dimensional quantitative structure activity relationships (3D QSAR) of a series of dimethoxyphenoxyphenoxypyrimidines and analogues which are known to be photosystem Ⅱ(PSⅡ)inhibitors have been studied using comparative molecular field analysis (CoMFA) method. The results suggest that the steric and electronic properties of substitutes at m position on the end phenyl ring have important influence on the Hill reaction inhibition.