Study on the Stereoselective Synthesis of Carbapenem Sidechain (2S,4S)-4-Acetylsulphanyl-2-[(S)-1-phenylethylcarbamoyl]-pyrrolidine-1-carboxylic Acid 4-Nitrobenzyl Ester

作     者：Qian LIU Gang FANG Li Ping WU Jian Mei CUI Xiao Tian LIANG Song WU Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050 

作者机构：Institute of Materia Medica Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100050 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2004年第15卷第12期

页      面：1395-1396页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：Stereoselective synthesis carbapenem sidechain acylation. 

摘      要：A stereoselective and economic synthesis of the carbapenem sidechain (2S, 4S)-4-ace-tylsulphanyl-2-[(S)1-phenylethyl-carbamoyl] pyrrolidine-1-carboxylic acid 4-nitrobenzylester was developed. Due to the effect of spatial hindrance, only the (2S,4S) diastereomer 3 wasobtained by coupling 1 and the inexpensive racemic 2 catalyzed by EEDQ.