New modified multiwalled carbon nanotubes paste electrode for electrocatalytic oxidation and determination of warfarin in biological and pharmaceutical samples

作     者：Masoumeh Taei Fardin Abedi Masoumeh Taei;Fardin Abedi

作者机构：帕亚莫.努尔大学化学系 

出 版 物：《Chinese Journal of Catalysis》 (催化学报（英文）)

年 卷 期：2016年第37卷第3期

页      面：436-445页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100704[医学-药物分析学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 10[医学] 

主　　题：ZnCrFeO4 Multiwalled carbon nanotubes Warfarin Electrochemical impedance spectroscopy Paste electrode 

摘      要：A novel sensor for the determination of warfarin based on a simple and sensitive method was developed on multiwalled-carbon-nanotube modified ZnCrFeO4 carbon paste electrodes（MWCNT/ZnCrFeO4/CPEs）. Cyclic voltammetry, differential pulse voltammetry, chronoamperometry, and electrochemical impedance spectroscopy were used to investigate the electrochemical behavior of warfarin at the chemically modified electrode. According to the results, MWCNT/ZnCrFeO4/CPEs showed high electrocatalytic activity for warfarin oxidation, producing a sharp oxidation peak current at about ＋0.97 vs Ag/AgCl reference electrode at pH = 4.0. The peak current was linearly dependent on warfarin concentration over the range of 0.02–920.0 μmol/L with a detection limit of 0.003 μmol/L. In addition, chronoamperometry was also used to determine warfarin＇s catalytic rate constant and diffusion coefficient at MWCNT/ZnCrFeO4/CPEs.