Genitourinary small-cell carcinoma： 11-year treatment experience

作     者：Kun Chang 

作者机构：Department of Urology Fudan University Shanghai Cancer Center Shanghai China Department of Oncology Fudan University Shanghai Cancer Center Shanghai China Department of Pathology Fudan University Shanghai Cancer Center Shanghai China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2014年第16卷第5期

页      面：705-709,I0007页

核心收录：

学科分类：10[医学] 

基　　金：Guide Project of Science and Technology Commission of Shanghai Municipality [124119a7300] Outstanding Young Talent Training Plan of Shanghai Municipal Commission of Health and Family Planning [XYQ2013102] International Cooperation and Exchange of Science and Technology Commission of Shanghai Municipality 

主　　题：bladder cancer diagnosis genitourinary small-cell carcinoma prognosis prostate cancer 

摘      要：The predictive factors of prognosis and treatment strategies for small-cell carcinoma （SCC） of the urinary tract are controversial. This study was aimed to investigate the clinical experience and management of patients with SCC of the urinary tract. We collected data of patients who were diagnosed with genitourinary SCC （GSCC） between 2002 and 2013 and were treated in the Fudan University Shanghai Cancer Center. A total of 18 patients were diagnosed with GSCC of which 10 originated from the prostate, seven from the bladder and one from the adrenal gland. The mean follow-up time was 15.5 months and progression-free survival （PFS） was 9.3 months. Primary tumor resection was attempted in 13 of 18 patients （72.2%） in whom radical surgery was performed in six of 14 （42.9%） limited disease patients. Most of the patients （13, 72.2%） received cisplatin-based chemotherapy. Patients who had normal lactic dehydrogenase （LDH） levels showed a significantly higher median PFS and overall survival （OS） compared with patients with high LDH levels （P = 0,030, P = 0.010）. Patients with limited disease treated with a radical operation experienced a non-significant （P = 0,211） longer PFS compared with patients who were not treated, but this reached statistical significance after analyzing OS （P = 0.211, P = 0.039）. Our patients showed a poor prognosis as reported previously. Serum LDH levels beyond the normal range indicate a poor prognosis. For GSCC patients who are diagnosed with limited disease, radical surgery is strongly recommended along with cisplatin-based chemotherapy,