Cytochrome P450 monooxygenase-mediated eicosanoid pathway:A potential mechanistic linkage between dietary fatty acid consumption and colon cancer risk

作     者：Weicang Wang Jianan Zhang Guodong Zhang 

作者机构：Department of Food ScienceUniversity of Massachusetts-AmherstAmherstMA01003USA Molecular and Cellular Biology ProgramUniversity of Massachusetts-AmherstAmherstMA01003USA 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2019年第8卷第4期

页      面：337-343页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 08[工学] 083202[工学-粮食、油脂及植物蛋白工程] 

基　　金：This research is supported by a new faculty start-up from the University of Massachusetts Amherst USDA NIFA2016-67017-24423 USDA NIFA 2019-67017-29248 USDA/HatchMAS00492 and NIH/NCIR03 CA218520(to G.Z.) 

主　　题：Linoleic acid Polyunsaturated fatty acids ω-3 Fatty acids Colon cancer Colonic inflammation Cytochrome P450 Eicosanoids 

摘      要：Human consumption of linoleic acid(LA,18:2ω-6,abundant in vegetable oils)is very *** experiments showed that excessive LA intake increased azoxymethane-induced colon tumorigenesis,however,the impact of excessive LA on colon cancer in human is not conclusive,making it difficult to make dietary recommendations for optimal intake of *** the molecular mechanisms of LA on colon tumorigenesis could help to clarify its health effect,and facilitate development of mechanismbased strategies for preventing colon *** studies show that the previously unappreciated cytochrome P450 monooxygenase-mediated eicosanoid pathway is upregulated in colon cancer and plays critical roles in its pathogenesis,and could contribute to the effects of dietary LA,as well asω-3 fatty acids,on colon *** this review,we will discuss recent studies about the roles of cytochrome P450 monooxygenases in fatty acid metabolism and its roles in colonic inflammation and colon cancer,and how this information could help us to clarify the health impacts of dietary fatty acids.