Impaired long-term potentiation and hippocampus-dependent memory formation in AQP4 knockout mice is rescued by GLT-1 activation

作     者：范军 

作者机构：Department of PharmacologyTongji Medical CollegeHuazhong University of Science and Technology 

出 版 物：《中国药理学与毒理学杂志》 (Chinese Journal of Pharmacology and Toxicology)

年 卷 期：2012年第3期

页      面：464-465页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：The project supported by NSFC(30930104 and 81171258) 

主　　题：GLT Impaired long-term potentiation and hippocampus-dependent memory formation in AQP4 knockout mice is rescued by GLT-1 activation AQP 

摘      要：OBJECTIVE Although the role of newly identified aquaporin 4(AQP4) in water transport has been extensively investigated,little is known about its contribution to hippocampal synaptic plasticity and *** it has been detected widely co-localized with glutamate transporter 1(GLT-1) in astrocytes,we thus investigated whether AQP4 was implicated in long-term potentiation(LTP) and memory formation via *** Using tissue immunofluorescence double staining to measure coexpression of AQP4 and *** was employed to detect the expression of *** vivo electrophysiological recording method was established to record the PS,and TBS was developed for the induction of *** fear conditioning test was used to evaluate hippocampus-dependent *** impregnation indicated the density of dendritic ***: Our present study demonstrated that AQP4 deficiency impaired hippocampal LTP and hippocampus-dependent memory formation and this impairment was mediated by the down-regulation of GLT-1 expression/function in hippocampus in AQP4 knockout(KO) mice,since it could be rescued by ceftriaxone(Cef),a stimulator of *** These results suggest that AQP4 functions as the modulator of synaptic plasticity and actively regulates learning and memory.