Single-particle cryo-EM: beyond the resolution

作     者：Jean-Paul Armache Yifan Cheng 

作者机构：Department of Biochemistry and Molecular Biology and the Huck Institutes of the Life SciencesPennsylvania State University Howard Hughes Medical Institute University of California San Francisco Department of Biochemistry and BiophysicsUniversity of California San Francisco 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2019年第6卷第5期

页      面：864-866页

核心收录：

学科分类：071011[理学-生物物理学] 0710[理学-生物学] 07[理学] 08[工学] 080401[工学-精密仪器及机械] 0804[工学-仪器科学与技术] 0803[工学-光学工程] 

基　　金：supported by various NIH grants:R01GM082893,R01GM098672,R01HL134183,P50GM082250(Nevan Krogan) P01GM111126(Robert Stroud) S10OD020054 and S10OD021741 

主　　题：Single-particle cryo-EM beyond the resolution 

摘      要：Structural biology aims to provide structural insights into our understandings of biological processes at the atomic *** structures of biological macromolecules are often determinedby one of the three major methods:Xray crystallography, NMR spectroscopy and cryo-electron microscopy (cryoEM) or, more specifically, single-particle