New O-superfamily conotoxins from Conus striatus inhabited near Chinese Hainan Island

作     者：Baisong Lu Fang Yu Jianhua Wang Siqing Zhao Dong Zhao Qiuyun Dai Peitang Huang Cuifen Huang 

作者机构：Inst Biotechnol Beijing 100071 Peoples R China 

出 版 物：《Chinese Science Bulletin》 (Chin. Sci. Bull.)

年 卷 期：2000年第45卷第5期

页      面：432-435页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：National Ocean High-Tech Foundation of China  (819-06-04) 

主　　题：conotoxin RACE conopeptide Conus striatus O-superfamily conotoxin. 

摘      要：Conotoxins are short peptide-toxins with specific targets and large diversity. They are usetul in analgesia, neuroprotection, detection of some kinds of deseases, and receptor and ion channel study. in order to explore the conotoxin resourses of Chinese oceans, rapid amplification of 3’ cDNA ends (RACE) method was utilized to systemically analyze the O-superfamily conotoxin content of Conus striatus inhabited near Chinese Hainan Island. Six new O-superfamily conopeptides were identified, one of which is highly homologous to MVIlA, an N-type calcium channel antagonist.