The prognostic impact of traditional Chinese medicine monomers on tumor-associated macrophages in non-small cell lung cancer

作     者：WAN Liang-Qin TAN Yan JIANG Miao HUA Qian 

作者机构：School of Acupuncture-Moxibustion and TuinaBeijing University of Chinese MedicineBeijing 100029China Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100029China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2019年第17卷第10期

页      面：729-737页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 0703[理学-化学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：supported by the National Natural Science Foundation of China(No.81473546) National Center for International Research(No.2015B01022) the Regional Collaborative Innovation Center of Tibetan Medicine(No.2017XTCX012) the Fundamental Research Funds for the Central Universities(No.2018-JYBZZ-XJSJJ011) 

主　　题：Lung cancer Tumor microenvironment Tumor-associated macrophages Traditional Chinese medicine (TCM) monomer Immunotherapy 

摘      要：Non-small cell lung cancer(NSCLC) accounts for 80%-85% of all lung malignancies and good diagnosis and prognosis of NSCLC are critical to the increase of its survival rate. Tumor-associated macrophages(TAM) abundantly present in numerous cancer types, and the role of TAMs in tumor biology and their prognostic value in cancer become major topics of interest. After various stimulations in the tumor microenvironment, TAMs develop into a M1(tumor-inhibitory) phenotype or M2(tumor-promoting) phenotype. Recent studies show that traditional Chinese medicine(TCM) monomers have markedly inhibitory actions for NSCLC through M1/M2 modulation. Due to the TCM monomers mainly covered five categories, i.e. terpenoids, flavonoids, polysaccharides, natural polyphenols, and alkaloids. Thus, we will discuss the regulation of TCM monomers on TAM involve in these five parts in this review. In addition, the potential role of TAMs as therapeutic targets will be discussed.