Knockout of MicroRNA-155 Ameliorates the Th17/Th9 Immune Response and Promotes Wound Healing
作者机构：Department of Otolaryngologythe First Hospital of WuhanWuhan 430022China Department of AnesthesiologyHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China Department of General SurgeryHubei Provincial Hospitalof Traditional Chinese MedicineWuhan 430061China Hubei Province Academy of Traditional Chinese MedicineWuhan 430074China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2019年第39卷第6期
页 面：954-964页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the Natural Science Foundation of Hubei Province(No.2018CFC819) Health Commission of Hubei Province Scientific Research Project(No.WJ2019F163 and No.WJ2019F165)
主 题：wound healing T cells miR155 C-maf IL-17A IL-9
摘 要：MiRNAs are integral for maintaining immune homeostasis and *** this study,qPCR analyses were performed to determine which miRNAs play an important role in wound ***,an experiment in a model of wound healing was performed,and histology,mRNA expression and T-cell subpopulations in wound tissue were *** accelerated experiments were performed by local injection of either rIL-17A and/or rlL-9 after wound *** vitro,the differentiation of Thl7/Th9 in miR-155^+/+ or miR-155^-/- mice was investigated,and the target genes of miR155 were *** our findings,miR-155^-/- in mice promoted wound healing and weakened T cell-mediated inflammation,especially in IL-17/IL-9,and less severe skin fibrosis developed in the ***-17A and/or rIL-9 could exacerbate inflammatory injury and delay wound *** also demonstrated that miR-155^-/- led to a defect in the differentiation of Th17/Th9 in vitro,and this effect of IL-17/IL-9 might be related to the expression of C-maf,which is a target gene of ***-155 regulated IL-17/IL-9-related inflammation in wound healing and might be a potential therapeutic target to attenuate the inflammatory response in wound tissue and promote the closure of wound injuries.
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