Overview of organic anion transporters and organic anion transporter polypeptides and their roles in the liver
Overview of organic anion transporters and organic anion transporter polypeptides and their roles in the liver作者机构：Department of Gastroenterology Affiliated Hospital Zunyi Medical University
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2019年第7卷第23期
页 面：3915-3933页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
主 题：Organic anion Substrate transport Liver fibrosis Liver cirrhosis Liver cancer Targeted therapy
摘 要：Organic anion transporters(OATs)and organic anion transporter polypeptides(OATPs)are classified within two SLC superfamilies,namely,the SLC22A superfamily and the SLCO superfamily(formerly the SLC21A family),*** are expressed in many tissues,such as the liver and kidney,and mediate the absorption and excretion of many endogenous and exogenous substances,including various *** are composed of 12 transmembrane polypeptide chains with the C-terminus and the N-terminus located in the cell *** and OATPs are abundantly expressed in the liver,where they mainly promote the uptake of various endogenous substrates such as bile acids and various exogenous drugs such as antifibrotic and anticancer ***,differences in the locations of glycosylation sites,phosphorylation sites,and amino acids in the OAT and OATP structures lead to different substrates being transported to the liver,which ultimately results in their different roles in the *** date,few articles have addressed these aspects of OAT and OATP structures,and we study further the similarities and differences in their structures,tissue distribution,substrates,and roles in liver diseases.
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