Photodynamic therapy based on organic small molecular fluorescent dyes

作     者：Li Li Yisha Chen Weijie Chen Ying Tan Haiyan Chen Jun Yin 

作者机构：Department of Biomedical EngineeringSchool of EngineeringState Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Key Laboratory of Pesticide and Chemical BiologyMinistry of EducationHubei International Scientific and Technological Cooperation Base of Pesticide and Green SynthesisInternational Joint Research Center for Intelligent BiosensingTechnology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China State Key Laboratory of Chemical OncogenomicsKey Laboratory of Chemical Biologythe Graduate School at ShenzhenTsinghua UniversityShenzhen 518055China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2019年第30卷第10期

页      面：1689-1703页

核心收录：

学科分类：1002[医学-临床医学] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the Natural Science Foundation Committee of China (NSFC,No.81671803) the National Key Research and Development Program (No.2017YFC0107700) the Outstanding Youth Foundation of Jiangsu Province (Nos.GX20171114003, BK20170030) Fok Ying Tung Education Foundation (No.161033) "Double First-Class" University Project (Nos.CPU2018GY06 and CPU2018GY24) the Priority Academic Program Development of Jiangsu Higher Education Institutions for their financial support the National Natural Science Foundation of China (Nos.21676113,21402057,21772054,21472059) Distinguished Young Scholar of Hubei Province (No.2018CFA079) for the financial support supported by the 111 Project (No.B17019) 

主　　题：Near-infrared fluorescent dyes Photodynamic therapy Cyanine BODIPY Phthalocyanine 

摘      要：Photodynamic therapy(PDT) has shown promise as an effective treatment modality for cancer and other localized diseases due to its noninvasive properties and spatiotemporal selectivity. Near-infrared(NIR)fluorescent dyes based on organic small molecules are characterized with low cytotoxicity, good biocompatibility and excellent phototoxicity, which are widely used in PDT. In this review, we attempt to summarize the development of imaging-induced PDT based on organic small molecules and classify it according to the structures of dyes including cyanines, 4,4-difluoro-4-bora-3 a,4 a-diaza-s-indacene(BODIPY) analogues, phthalocyanine and other agents such as rhodamine analogues.