Reduction patterns of Japanese encephalitis incidence following vaccine introduction into long-term expanded program on immunization in Yunnan Province,China

作     者：Xiao-Ting Hu Qiong-Fen Li Chao Ma Zhi-Xian Zhao Li-Fang He Ting-Ting Tang Wen Yu Philip Owiti Hu Xiao-Ting;Li Qiong-Fen;Ma Chao;Zhao Zhi-Xian;He Li-Fang;Tang Ting-Ting;Yu Wen;Owiti Philip

作者机构：Expand ed Program on ImmunizationYunnan Center for Disease Control and PreventionNO.158 DongSi StreetXiShan DistrictKunming CityYunnan ProvinceChina National Immunization ProgramChinese Center for Disease Control and Prevention27 Nanwei RoadXicheng DistrictBeijingChina The International Union Against Tuberculosis and Lung DiseaseParisFrance The National TuberculosisLeprosy and Lung Disease ProgramNairobiKenya 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2019年第8卷第6期

页      面：84-91页

核心收录：

学科分类：0202[经济学-应用经济学] 02[经济学] 020205[经济学-产业经济学] 

基　　金：This study was conducted as part of the routine duties of the principal author at the Yunnan Provincial Centre for Disease Control and Prevention and required no additional funding resources Funding for the costs of publication in an open-access,peer-reviewed journal was supported by Yunnan Provincial Centre for Disease Control and Prevention 

主　　题：Vaccination program Incidence Surveillance system Epidemiology Operational research 

摘      要：Background:Japanese encephalitis(JE)is a leading cause of childhood viral encephalitis both at global level and in *** is recommended as a key strategy to control *** China most JE cases have been reported in southwest provinces,which include *** this study,we quantify the epidemiological shift of JE in Yunnan Province from 2005 to 2017,covering before and after the introduction of JE vaccination into routine Expanded Program on Immunization(EPI)in ***:We used routinely collected data in the case-based JE surveillance system from 2005 through 2017 in *** were reported from hospital and county-level Centers for Disease Control in line with the National JE Surveillance *** data were extracted,analysed and presented in appropriate *** coverage was estimated from actual JE doses administered and new births for each ***:A total 4780 JE cases(3077 laboratory-confirmed,1266 clinical and 437 suspected)were reported in the study *** of JE(per 100000 population)increased from 0.95 in 2005 to 1.69 in *** increase in vaccination coverage,incidence rates decreased steadily from 1.16 in 2009 to 0.17 in ***,seasonality remained similar across the years,peaking in ***(bordering Myanmar and Laos),Dehong(bordering Myanmar),and Zhaotong(an inland prefecture)had the highest incidence rates of 2.3,1.9,and 1.6,respectively.97%of all cases were among local *** vaccination coverage increased(and incidence decreased),proportion of JE cases among children20 years old increased from 12 to 48%.There were a large number of JE cases with unknown treatment outcomes,especially in the earlier years of the surveillance ***:The 13-year JE surveillance data in Yunnan Province showed dramatic decrease of total incidence and a shift from children to *** vaccinati