Multiple roles of PTEN isoforms PTENα and PTENβ in cellular activities and tumor development

作     者：Hui Liang Yuxin Yin 

作者机构：Institute of Systems Biomedicine Department of Pathology School of Basic Medical Sciences Peking-Tsinghua Center for Life SciencesPeking University Health Science Center 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2019年第62卷第12期

页      面：1722-1724页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the the National Key Research and Development Program of China (2016YFA0500302) the National Natural Science Foundation of China (81430056, 31420103905, 81621063) the Beijing Natural Science Foundation (7161007) the Lam Chung Nin Foundation for Systems Biomedicine 

主　　题：PI3K/AKT Hopkins PTEN 

摘      要：PTEN is a powerful tumor suppressor gene frequently mutated in human cancers and autism spectrum *** protein is located both in the cytoplasm and nucleus and can also be secreted from *** best characterized function of PTEN is its ability to dephosphorylate Ptdlns(3,4,5)P3 and converts it back into PIP2 in the cytoplasm,therefore antagonizing the PI3K/AKT pathway which is mainly involved in regulation of cell growth,differentiation,proliferation and invasion(Hopkins et al.,2014;Lee et al.,2018).It has been demonstrated that the nuclear PTEN mainly participates in the maintenance of chromosome stability and regulation of DNA repair pathway(Shen et al.,2007).More recently,nuclear PTEN is also shown to interact with the splicing machinery,spliceosome,to regulate its assembly and pre-mRNA splicing(Shen et al.,2018).In human genome,there is only one gene that encodes ***,more and more lines of evidence indicate that the PTEN gene may translate isoforms that function differently from canonical PTEN protein.