The crosstalk between autophagy and ferroptosis:what can we learn to target drug resistance in cancer?

作     者：Yulu Zhou Yong Shen Cong Chen Xinbing Sui Jingjing Yang Linbo Wang Jichun Zhou 

作者机构：Department of Surgical OncologySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang ProvineeHangzhou 310016China Department of Breast SurgeryFirst Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006China Department of Medical OncologyHolistic Integrative Oncology Institutes and Holistic Integrative Cancer Center of Traditional Chinese and Western MedicineThe Affiliated Hospital of Hangzhou Normal UniversityCollege of MedicineHangzhou Normal UniversityHangzhou 310012China Department of Cancer PharmacologyHolistic Integrative Pharmacy InstitutesCollege of MedicineHangzhou Normal UniversityHangzhou 310012China Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Provinee and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang ProvineeHangzhou Normal UniversityHangzhou 310012China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2019年第16卷第4期

页      面：630-646页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (Grant No. 81602471, 81672729, 81672729, 81874380 and 81672932) Zhejiang Provincial Natural Science Foundation of China under Grants (Grant No. LY19H160055, LY19H160059) by Zheng Shu Medical Elite Scholarship Fund by grant from sub-project of China National Program on Key Basic Research Project (973 Program) (Grant No. 2014CB744505) Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars (Grant No. LR18H160001) Zhejiang Province Medical Science and Technology Project (Grant No. 2017RC007) Talent Project of Zhejiang Association for Science and Technology (Grant No. 2017YCGC002) Zhejiang Province Science and Technology Project of TCM (Grant No. 2019ZZ016) 

主　　题：Autophagy ferroptosis crosstalk cancer drug resistance 

摘      要：Autophagy is a conserved intracellular degradation system that plays a dual role in cell death;thus,therapies targeting autophagy in cancer are somewhat controversial.Ferroptosis is a new form of regulated cell death featured with the iron-dependent accumulation of lethal lipid ROS.This pathway is morphologically,biochemically and genetically distinct from other forms of cell death.Accumulating studies have revealed crosstalk between autophagy and ferroptosis at the molecular level.In this review,we summarize the mechanisms of ferroptosis and autophagy,and more importantly,their roles in the drug resistance of cancer.Numerous connections between ferroptosis and autophagy have been revealed,and a strong causal relationship exists wherein one process controls the other and can be utilized as potential therapeutic targets for cancer.The elucidation of when and how to modulate their crosstalk using therapeutic strategies depends on an understanding of the fine-tuned switch between ferroptosis and autophagy,and approaches designed to manipulate the intensity of autophagy might be the key.