Peroxisome proliferator-activated receptor γ and colorectal cancer

作     者：Yun Dai Wei-Hong Wang 

作者机构：Yun Dai Wei-Hong Wang Department of Gastroenterology Peking University First Hospital Beijing 100034 China. 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2010年第2卷第3期

页      面：159-164页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Colorectal cancer Peroxisome proliferator-activated receptors Ligand Tumor suppression 

摘      要：Peroxisome proliferator-activated receptors(PPARs) are members of the nuclear hormone receptor superfamily and ligand-activated transcription ***γ plays an important role in adipocyte differentiation,lipid storage and energy dissipation in adipose tissue,and is involved in the control of inflammatory reactions as well as in glucose metabolism through the improvement of insulin *** evidence has demonstrated that activation of PPARγ has an antineoplastic effect in tumors,including colorectal *** expression of PPARγ is detected in human colon cancer cell lines and *** review describes the molecular mechanisms by which PPARγ regulates tumorigenesis in colorectal cancer,and examines current clinical trials evaluating PPARγ agonists as therapeutic agents for colorectal cancer.